Written by Scientists have found a way to disarm a protein thought to play a key role in leukaemia and other cancers.
The breakthrough raises hopes of a new type of therapy that could treat cancer and other diseases.
Previous attempts to neutralise the protein had failed, leading experts to conclude it was effectively “undruggable”.
The study, carried out by the US Dana-Farber Cancer Institute, features in the journal Nature.
The protein is one of the body’s transcription factors, which turn genes on or off and set in motion genetic cascades that control how cells grow and develop. They also help fuel the growth of tumours.
The transcription factor targeted in the latest study is a protein called Notch.
The gene responsible for manufacturing the protein is often damaged or mutated in patients with a form of blood cancer known as T-cell acute lymphoblastic leukaemia (ALL).
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