Two prostate cancer victims stage dramatic recovery after drug trial

Two men with advanced and inoperable prostate cancer have made dramatic recoveries after being treated with an experimental antibody drug.
Rodger Nelson and Fructuoso Solano-Revuelta are now both cancer-free and have returned to normal life.
They were taking part in the trial of drug called ipilimumab that boosts the immune system.
Before treatment at the Mayo Clinic in Rochester, Minnesota, US, each of them had aggressive tumours that had grown well beyond the prostate gland into abdominal areas.
Trial leader Dr Eugene Kwon said: ‘The goal of the study was to see if we could modestly improve upon current treatments for advanced prostate cancer.
‘The candidates for this study were people who didn’t have a lot of other options. However, we were startled to see responses that far exceeded any of our expectations.’
First, the patients received traditional hormone therapy to remove testosterone, which fuels prostate cancer.
Researchers then introduced a single dose of ipilimumab. The drug is an antibody which builds on the hormone therapy and boosts the immune system’s response to the cancer.
Both patients saw their prostate specific antigen (PSA) levels drop to the point where they became eligible for surgery. PSA is a protein in the blood that allows doctors to monitor prostate cancer.
When the surgeons made their incisions, they had a surprise.
Mayo clinic urologist Dr Michael Blute said: ‘The tumours had shrunk dramatically.
I had never seen anything like this before. I had a hard time finding the cancer. At one point the pathologist asked if we were sending him samples from the same patient.’
One patient underwent radiation treatment after surgery.
Further research is planned to understand more about the mechanisms of the antibody and how best to use it on patients.
Dr Kwon said: ‘This is one of the holy grails of prostate cancer research. We’ve been looking for this for years.’
John Neate, chief executive of The Prostate Cancer Charity, said: ‘The reported results of the experimental treatment of these two patients showed dramatic shrinkage of the tumour, allowing surgery to take place.
‘If these early and small-scale results are replicated in larger trials, this represents a potentially very exciting development.
‘We urgently need a wider range of treatment options for prostate cancer which has spread outside the prostate gland and this research is a welcome indication of potential progress in this area.
‘It must be remembered that this is a small trial, however, and the findings are preliminary results.
‘The Prostate Cancer Charity eagerly awaits further research and looks forward with anticipation to exploring the results.’
Meanwhile researchers have claimed that green tea may help slow the advance of prostate cancer. 
Men with the disease who consumed the active ingredients found in green tea had lower levels of markers that predict its progress, a U.S. study found.
It involved the use of Polyphenon E, a supplement containing green tea’s active compounds which is under investigation in a number of clinical trials.
Researcher Dr James Cardelli of the Feist-Weiller Cancer Centre, Louisiana, said: ‘It may have the potential to lower the incidence and slow the progression of prostate cancer.’
Prostate cancer affects around 35,000 men in the UK each year and claims some 10,000 lives. 
Green tea differs from black tea in that it is not fermented before drying.
This fermentation process appears to reduce the content of flavonoids – beneficial antioxidants – by up to 90 per cent.
Recent studies have shown that green tea may be beneficial for the arteries, lowers ‘bad’ cholesterol and blood pressure, and reduces harmful liver enzymes.
Drinking green tea could help stave off cancer, with a study showing just four cups of green tea a day reverses cell damage in heavy smokers that might lead to the development of tumours.
The American study included 26 men, aged 41 to 72 years, diagnosed with prostate cancer and about to have surgery.
They took a daily dose of Polyphenon E, equivalent to about 12 cups of normally brewed concentrated green tea, for around a month on average.
Findings showed a significant reduction in scores of PSA (prostate specific antigen), a protein marker used to chart progress of the disease, and two other biomarkers. Some patients had reductions of more than 30 per cent.
There were few side effects, says a report in Cancer Prevention Research journal.
It follows a year-long trial in Italy which showed that drinking green tea cut the risk in men with pre-cancerous signs of the disease.
The active ingredients include polyphenols, which have antioxidant properties believed to protect against cell damage.

TV Series

Prison Break – TV Series

I will recomand it as being a good one to see, you should at least try one or two episode and if still don’t like maybe you should tell me what should i try.I start watching the first one in a moment when i had no interest in watching TV,news, it was all related to PC more or less, colecting all data from the Internet. I got to say that pretty much i wasn’t like TV Series but i got to say that this one was nice and still is i’am on IV Series , episode 10, i watch when i can, but is good.


Online surveys and open source

Recently, I ‘ve  tested the LimeSurvey open source survey software (formerly phpsurveyor).I used LimeSurvey for one  survey, it’s a nice solution that offers easy build-in solution for a survey,you can manage to change the template to easy customise the content based upon templates that the offers. It’s  a nice solution, i’ve tested using php and mysql,  and i have to say that it’s a good open source  software for creating surveys.

  • has many decent out-of-the-box templates.
  • you can easy do: monitoring survey statuses, and exporting results into a variety of formats incluting native Excel spreadsheets.
  • you have  survey flow options (question grouping, and display of questions by groups, singly, or in combination).
  • save and auto-resume features readily available for users who choose not to complete the survey in one sitting.
  • supports custom “success / thank you” landing pages.
  • automatically generated PDF and “printable” survey versions.

LimeSurvey is a valuable survey tool,I’d strongly recommend the software to anyone with at least a fundamental level of server-side scripting knowledge (installing server-level scripts and databases). Give it a shot!


Presenting Romania

As a friend of mine, has requested some presentation/infos about Romania, i have found
an old TV one, mostly seen on CNN, Romania simply surprising

and yet some photos with places to see in romania

i wiss you a nice holiday 🙂

Mac OS X

Mac OS X 10.5.7 in my MSI EX600 laptop

I’ve recently updated to 10.5.7 and i may say that it’s a better in stability, i’am using ideneb only for test in my laptop, and i used for update iDeneb Combo Upgrade KIT 10.5.7 for my existing 10.5.6 version.
Apple released Mac OS X 10.5.7, a recommended update for all Mac OS X 10.5.x Leopard users that includes general operating system fixes that enhance the stability, compatibility and security of Macs. Separately, the company released Safari 3.2.3, an update to Safari 4.0 beta and security updates for Mac OS X 10.4 Tiger.
Mac OS X 10.5.7
The Mac OS X 10.5.7 client software is available as a 442MB delta download for Macs running Mac OS X 10.5.6 and as a 729MB combo update for Macs running earlier versions of the Leopard operating system. A list of specific enhancements included in the release follows:
* Includes latest security fixes.
* Includes additional RAW image support for several third-party cameras
* Improves performance of video playback and cursor movements for recent Macs with NVIDIA graphics
* Resolves an issue with Dvorak keyboard layout in Mac OS X 10.5.6
* Improves the reliability and accuracy of Unit Converter, Stocks, Weather and Movies Dashboard widgets
* Addresses a situation that may cause issues when logging into Gmail
* Improves reliability when syncing contacts with Yahoo!
* Expansion Slot Utility for Mac Pro now reports the correct PCIe slot configuration
* Improves network performance when connected to certain Ethernet switches that have Flow Control enabled
* Improves stability for network home directories hosted by Mac OS X Server v10.4
* Improves Finder search results for network volumes that may not support Spotlight searching, such as Mac OS X Server v10.4, Time Capsule, and third-party AFP servers
* Includes several improvements to Directory Service and Client Management, which are described in the About Mac OS X Server 10.5.7 Update article
* Improves overall reliability with CalDav
* Improves reliability when automatically syncing with MobileMe
* Addresses reliability and sync issues with Notes
* Addresses an issue that may cause the BCC field to populate incorrectly when redirecting a message from the Sent mailbox
Parental Controls
* Improves consistency with Parental Controls and application restrictions
* Addresses an issue in which time limits may not work properly with full-screen games and Fast User Switching
* Resolves an issue that may cause certain third-party printers to print to the incorrect paper tray
* Non-admin user accounts can now be allowed to add and remove printers by enabling Parental Controls and selecting “Can administer printers”
* Includes other printing reliability and stability improvements